Article
Macrophage-specific overexpression of group IIa sPLA2 increases atherosclerosis and enhances collagen deposition.
Journal of lipid research - 1 Feb 2005
Ghesquiere Stijn A I, Gijbels Marion J J, Anthonsen Marit, van Gorp Patrick J J, van der Made Ingeborg, Johansen Berit, Hofker Marten H, de Winther Menno P J
Abstract excerpt
Atherosclerosis is a chronic inflammatory disease of the vessel wall characterized by the accumulation of lipid-laden macrophages and fibrotic material. The initiation of the disease is accompanied by the accumulation of modified lipoproteins in the vessel wall. Group IIa secretory phospholipase A2 (sPLA2 IIa) is a key candidate player in the enzymatic modification of low density lipoproteins. To study the role...
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