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Article

Association of Hck genetic polymorphisms with gene expression and COPD.

Human genetics - 1 Jan 2007

Zhang Xiaozhu, Mahmudi-Azer Salahaddin, Connett John E, Anthonisen Nicholas R, He Jian-Qing, Paré Peter D, Sandford Andrew J

Abstract excerpt

Polymorphonuclear leukocytes (PMNs) are major effector cells in the chronic airway inflammation in chronic obstructive pulmonary disease (COPD). PMN degranulation is associated with degradation of extracellular matrix and tissue damage. Hck is an essential molecule in the signaling pathway regulating PMN degranulation. We hypothesized that polymorphisms affect the expression level of Hck, which, in turn,...

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PMID: 17024369
DOI: 10.1007/s00439-006-0253-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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