Article
Female-specific association of C-C chemokine receptor 5 gene polymorphisms with Löfgren's syndrome.
Journal of molecular medicine (Berlin, Germany) - 1 May 2008
Fischer Annegret, Valentonyte Ruta, Nebel Almut, Nothnagel Michael, Müller-Quernheim Joachim, Schürmann Manfred, Schreiber Stefan
Abstract excerpt
C-C chemokine receptors have been suggested to play an important role in sarcoidosis pathogenesis. Previous investigation of the C-C chemokine receptor 5 (CCR5) gene revealed the association of the HHC haplotype with "persistent lung involvement" in two European sarcoidosis populations. Based on this finding, we investigated a possible association of the HHC haplotype and its marker alleles in an extended German...
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