Article
Tissue-specific alternative splicing of hybrid Shaker/lacZ genes correlates with kinetic differences in Shaker K+ currents in vivo.
Neuron - 1 Mar 1995
Mottes J R, Iverson L E
Abstract excerpt
Alternative splicing of the Shaker (Sh) locus of Drosophila generates several transcripts with divergent 5' and 3' domains that produce kinetically distinct K+ currents in Xenopus oocytes. Although suggestive that alternative splicing may be involved in generating K+ channel diversity, clear tiss...
Topics
- Alternative Splicing
- Animals
- Animals, Genetically Modified
- Base Sequence
- Drosophila
- Drosophila Proteins
- Genetic Variation
- HSP70 Heat-Shock Proteins
- Molecular Sequence Data
- Muscle Development
- Muscles
- Mutagenesis, Insertional
- Neurons
- Oligodeoxyribonucleotides
- Photoreceptor Cells, Invertebrate
- Potassium Channels
- Promoter Regions, Genetic
- Pupa