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Article

Functional expression of Shaker K+ channels in cultured Drosophila "giant" neurons derived from Sh cDNA transformants: distinct properties, distribution, and turnover.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Feb 1995

Zhao M L, Sable E O, Iverson L E, Wu C F

Abstract excerpt

Expression of transgenic Shaker (Sh) channels has not previously been examined in Drosophila neurons. We studied K+ current by whole-cell recording in cultured "giant" neurons derived from germline transformants. Independent lines were generated by using a P-element vector, in which transcription of the 29-4 cDNA, one of the Sh splicing variants (Iverson and Rudy, 1990), was under the control of a heat shock...

Topics

4-Aminopyridine
Animals
Animals, Genetically Modified
Base Sequence
Cells, Cultured
DNA, Complementary
Drosophila
Electric Conductivity
Hot Temperature
Kinetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Probes

Molecular Sequence Data

Mutation

Neurons

Potassium Channels

Shock

Time Factors

Tissue Distribution

Source

Open in PubMed Open full text

Identifiers

PMID: 7869107
PMCID: PMC6577804

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7869107-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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