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Article

Bromodomain and histone acetyltransferase domain specificities control mixed lineage leukemia phenotype.

Cancer research - 15 Oct 2006

Santillan Donna A, Theisler Catherine M, Ryan Amanda S, Popovic Relja, Stuart Tara, Zhou Ming-Ming, Alkan Serhan, Zeleznik-Le Nancy J

Abstract excerpt

A critical unanswered question about mixed lineage leukemia (MLL) is how specific MLL fusion partners control leukemia phenotype. The MLL-cyclic AMP-responsive element binding protein-binding protein (CBP) fusion requires both the CBP bromodomain and histone acetyltransferase (HAT) domain for transformation and causes acute myelogenous leukemia (AML), often preceded by a myelodysplastic phase. We did...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to p300-CBP Transcription Factors

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Source

Identifiers

PMID: 17047066
DOI: 10.1158/0008-5472.CAN-06-2597

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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