Article
Automethylation activities within the mixed lineage leukemia-1 (MLL1) core complex reveal evidence supporting a "two-active site" model for multiple histone H3 lysine 4 methylation.
The Journal of biological chemistry - 10 Jan 2014
Patel Anamika, Vought Valarie E, Swatkoski Stephen, Viggiano Susan, Howard Benny, Dharmarajan Venkatasubramanian, Monteith Kelsey E, Kupakuwana Gillian, Namitz Kevin E, Shinsky Stephen A, Cotter Robert J, Cosgrove Michael S
Abstract excerpt
The mixed lineage leukemia-1 (MLL1) core complex predominantly catalyzes mono- and dimethylation of histone H3 at lysine 4 (H3K4) and is frequently altered in aggressive acute leukemias. The molecular mechanisms that account for conversion of mono- to dimethyl H3K4 (H3K4me1,2) are not well understood. In this investigation, we report that the suppressor of variegation, enhancer of zeste, trithorax (SET) domains...
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