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Article

Conformation of the AcrB multidrug efflux pump in mutants of the putative proton relay pathway.

Journal of bacteriology - 1 Oct 2006

Su Chih-Chia, Li Ming, Gu Ruoyu, Takatsuka Yumiko, McDermott Gerry, Nikaido Hiroshi, Yu Edward W

Abstract excerpt

We previously reported the X-ray structures of wild-type Escherichia coli AcrB, a proton motive force-dependent multidrug efflux pump, and its N109A mutant. These structures presumably reflect the resting state of AcrB, which can bind drugs. After ligand binding, a proton may bind to an acidic residue(s) in the transmembrane domain, i.e., Asp407 or Asp408, within the putative network of electrostatically...

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Identifiers

PMID: 17015668
DOI: 10.1128/JB.00684-06
PMCID: PMC1636240

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Conformation of the AcrB multidrug efflux pump in mutants of the putative proton relay pathway.PMID 17015668Read ↗

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