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Article

A critical role of a carboxylate in proton conduction by the ATP-binding cassette multidrug transporter LmrA.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2005

Shilling Richard, Federici Luca, Walas Fabien, Venter Henrietta, Velamakanni Saroj, Woebking Barbara, Balakrishnan Lekshmy, Luisi Ben, van Veen Hendrik W

Abstract excerpt

The ATP binding cassette (ABC) transporter LmrA from the bacterium Lactococcus lactis is a homolog of the human multidrug resistance P-glycoprotein (ABCB1), the activity of which impairs the efficacy of chemotherapy. In a previous study, LmrA was shown to mediate ethidium efflux by an ATP-dependent proton-ethidium symport reaction in which the carboxylate E314 is critical. The functional importance of this key...

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16040836
DOI: 10.1096/fj.04-3558fje

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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