Article
Mutations in the proximal binding site and F-loop of AdeJ confer resistance to efflux pump inhibitors.
Antimicrobial agents and chemotherapy - 6 Aug 2025
Saral Sariyer Aysegul, Leus Inga V, Tambat Rushikesh, Farjana Mithila, Olvera Marcela, Rukmani Shalini J, Sariyer Emrah, Smith Jeremy C, Parks Jerry M, Walker John K, Zgurskaya Helen I
Abstract excerpt
Multidrug efflux is one of the major mechanisms of antibiotic resistance in gram-negative bacteria. Inhibitors of efflux pumps potentiate the activities of antibiotics, and their discovery could lead to new therapeutic options. The AdeIJK pump in Acinetobacter baumannii is a promising target for efflux pump inhibitors (EPIs) due to its high clinical importance and conservation, and several classes of EPIs...
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