Article
Episodic memory performance predicted by the 2bp deletion in exon 6 of the "alpha 7-like" nicotinic receptor subunit gene.
The American journal of psychiatry - 1 Oct 2006
Dempster Emma L, Toulopoulou Timothea, McDonald Colm, Bramon Elvira, Walshe Muriel, Wickham Harvey, Sham Pak C, Murray Robin M, Collier David A
Abstract excerpt
OBJECTIVE: There is evidence of linkage between chromosome 15q14 and the P50 auditory evoked response, a heritable neuropsychological marker associated with increased risk of schizophrenia. Chromosome 15q14 harbors the alpha-7 nicotinic receptor subunit gene (CHRNA7) and a hybrid gene of unknown function (CHRFAM7A). CHRNA7 is involved in memory formation, a core dysfunction in schizophrenia. The authors set out...
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