Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence for linkage disequilibrium between the alpha 7-nicotinic receptor gene (CHRNA7) locus and schizophrenia in Azorean families.

American journal of medical genetics - 8 Dec 2001

Xu J, Pato M T, Torre C D, Medeiros H, Carvalho C, Basile V S, Bauer A, Dourado A, Valente J, Soares M J, Macedo A A, Coelho I, Ferreira C P, Azevedo M H, Macciardi F, Kennedy J L, Pato C N

Abstract excerpt

Recent studies have suggested that the alpha 7-nicotinic receptor gene (CHRNA7) may play a role in the pathogenesis of schizophrenia. The alpha 7-nicotinic receptor gene (CHRNA7) is involved in P50 auditory sensory gating deficits, and the genomic locus for this gene lies in the chromosome 15q13-14 regions. The human gene is partially duplicated (exons 5-10) with four novel upstream exons. The marker D15S1360 has...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to alpha7 Nicotinic Acetylcholine Receptor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Family Health

Share to Linkage Disequilibrium

Share to Microsatellite Repeats

Share to Receptors, Nicotinic

Share to Schizophrenia

Source

Identifiers

PMID: 11803513
DOI: 10.1002/ajmg.1549

Genes

CHRNA7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence for linkage disequilibrium between the alpha 7-nicotinic receptor gene (CHRNA7) locus and schizophrenia in Azorean families.PMID 11803513Read ↗

Comparison of polymorphisms in the alpha7 nicotinic receptor gene and its partial duplication in schizophrenic and control subjects.Semantic proximity Read ↗

Population-based and family-based association studies of an (AC)n dinucleotide repeat in alpha-7 nicotinic receptor subunit gene and schizophrenia.Semantic proximity Read ↗

Further investigation of a chromosome 15 locus in schizophrenia: analysis of affected sibpairs from the NIMH Genetics Initiative.Semantic proximity Read ↗

Evidence of association between smoking and alpha7 nicotinic receptor subunit gene in schizophrenia patients.Semantic proximity Read ↗

Association of the 5'-upstream regulatory region of the alpha7 nicotinic acetylcholine receptor subunit gene (CHRNA7) with schizophrenia.Semantic proximity Read ↗

Multiple genes in the 15q13-q14 chromosomal region are associated with schizophrenia.Semantic proximity Read ↗

No evidence for linkage between schizophrenia and markers at chromosome 15q13-14.Semantic proximity Read ↗

Linkage of M5 muscarinic and alpha7-nicotinic receptor genes on 15q13 to schizophrenia.Semantic proximity Read ↗

Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia.Semantic proximity Read ↗

A 2-base pair deletion polymorphism in the partial duplication of the alpha7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia.Semantic proximity Read ↗

Evidence for the multigenic inheritance of schizophrenia.Semantic proximity Read ↗

Regulation of alpha7-nicotinic receptor subunit and alpha7-like gene expression in the prefrontal cortex of patients with bipolar disorder and schizophrenia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.