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Article

Inhibitory neurophysiological deficit as a phenotype for genetic investigation of schizophrenia.

American journal of medical genetics - 1 Jan 2000

Freedman R, Adams C E, Adler L E, Bickford P C, Gault J, Harris J G, Nagamoto H T, Olincy A, Ross R G, Stevens K E, Waldo M, Leonard S

Abstract excerpt

Many investigators have proposed that biological endophenotypes might facilitate the genetic analysis of schizophrenia. A deficit in the inhibition of the P50 evoked response to repeated auditory stimuli has been characterized as a neurobiological deficit in schizophrenia. This deficit is linked to a candidate gene locus, the locus of the alpha7-nicotinic cholinergic receptor subunit gene on chromosome 15q14....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 10813805
DOI: 10.1002/(sici)1096-8628(200021)97:1<58::aid-ajmg8>3.0.co;2-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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