A 2-base pair deletion polymorphism in the partial duplication of the alpha7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia.

doi:10.1016/j.brainres.2009.07.041

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Article

A 2-base pair deletion polymorphism in the partial duplication of the alpha7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia.

Brain research - 29 Sept 2009

Sinkus Melissa L, Lee Michael J, Gault Judith, Logel Judith, Short Margaret, Freedman Robert, Christian Susan L, Lyon Jennifer, Leonard Sherry

Abstract excerpt

Multiple genetic linkage studies support the hypothesis that the 15q13-14 chromosomal region contributes to the etiology of schizophrenia. Among the putative candidate genes in this area are the alpha7 nicotinic acetylcholine receptor gene (CHRNA7) and its partial duplication, CHRFAM7A. A large chromosomal segment including the CHRFAM7A gene locus, but not the CHRNA7 locus, is deleted in some individuals. The...

Topics

Black or African American
Alleles
Base Sequence
Blotting, Southern
Chromosomes, Human, Pair 15
Female
Gene Dosage
Genetic Predisposition to Disease
Genotype
Hispanic or Latino

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

In Situ Hybridization, Fluorescence

Male

Patient Selection

Polymorphism, Genetic

Receptors, Nicotinic

Reverse Transcriptase Polymerase Chain Reaction

Schizophrenia

Source

Open in PubMed Open full text

Identifiers

PMID: 19631623
DOI: 10.1016/j.brainres.2009.07.041
PMCID: PMC2747474

Genes

CHRNA7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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