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Article

Association of the 5'-upstream regulatory region of the alpha7 nicotinic acetylcholine receptor subunit gene (CHRNA7) with schizophrenia.

Schizophrenia research - 1 Apr 2009

Stephens Sarah H, Logel Judith, Barton Amanda, Franks Alexis, Schultz Jessica, Short Margaret, Dickenson Jane, James Benjamin, Fingerlin Tasha E, Wagner Brandie, Hodgkinson Colin, Graw Sharon, Ross Randal G, Freedman Robert, Leonard Sherry

Abstract excerpt

BACKGROUND: The alpha7 neuronal nicotinic acetylcholine receptor subunit gene (CHRNA7) is localized in a chromosomal region (15q14) linked to schizophrenia in multiple independent studies. CHRNA7 was selected as the best candidate gene in the region for a well-documented endophenotype of schizophrenia, the P50 sensory processing deficit, by genetic linkage and biochemical studies. METHODS: Subjects included...

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Share to alpha7 Nicotinic Acetylcholine Receptor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 15

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Source

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Identifiers

PMID: 19181484
DOI: 10.1016/j.schres.2008.12.017
PMCID: PMC2748327

Genes

CHRNA7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of the 5'-upstream regulatory region of the alpha7 nicotinic acetylcholine receptor subunit gene (CHRNA7) with schizophrenia.PMID 19181484Read ↗

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Evidence for association of the non-duplicated region of CHRNA7 gene with bipolar disorder but not with Schizophrenia.Semantic proximity Read ↗

Linkage disequilibrium analysis of the CHRNA7 gene and its partially duplicated region in schizophrenia.Semantic proximity Read ↗

Comparison of polymorphisms in the alpha7 nicotinic receptor gene and its partial duplication in schizophrenic and control subjects.Semantic proximity Read ↗

The promoter -194 C polymorphism of the nicotinic alpha 7 receptor gene has a protective effect against the P50 sensory gating deficit.Semantic proximity Read ↗

The -2 bp deletion in exon 6 of the 'alpha 7-like' nicotinic receptor subunit gene is a risk factor for the P50 sensory gating deficit.Semantic proximity Read ↗

Association Study of CHRNA7 Promoter Variants with Sensory and Sensorimotor Gating in Schizophrenia Patients and Healthy Controls: A Danish Case-Control Study.Semantic proximity Read ↗

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