Article
Evidence of association between smoking and alpha7 nicotinic receptor subunit gene in schizophrenia patients.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Aug 2004
De Luca Vincenzo, Wong Albert H C, Muller Daniel J, Wong Gregory W H, Tyndale Rachel F, Kennedy James L
Abstract excerpt
A number of studies have suggested that the alpha-7-nicotinic receptor D15S1360 polymorphism is associated with schizophrenia and a deficiency in the normal inhibition of the P50 auditory-evoked response. Schizophrenia patients and some of their unaffected relatives show a failure of inhibition in their 50-ms response to the second of a pair of tones. Biochemical studies have suggested that the alpha7 nicotinic...
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