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Article

Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia.

Archives of general psychiatry - 1 Dec 2002

Leonard Sherry, Gault Judith, Hopkins Jan, Logel Judith, Vianzon Ruby, Short Margaret, Drebing Carla, Berger Ralph, Venn Diana, Sirota Pinkhas, Zerbe Gary, Olincy Ann, Ross Randal G, Adler Lawrence E, Freedman Robert

Abstract excerpt

BACKGROUND: The alpha7 neuronal nicotinic acetylcholine receptor subunit gene (CHRNA7) has been implicated as a candidate gene for schizophrenia, and for an auditory sensory processing deficit found in the disease, by both genetic linkage at 15q14 and biochemical data. The expression of CHRNA7 is reduced in several brain regions in schizophrenic subjects compared with control subjects. This study presents DNA...

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Share to alpha7 Nicotinic Acetylcholine Receptor
Share to Chromosomes, Human, Pair 15

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evoked Potentials, Auditory

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Share to Polymorphism, Single-Stranded Conformational

Share to Receptors, Nicotinic

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Source

Identifiers

PMID: 12470124
DOI: 10.1001/archpsyc.59.12.1085

Genes

CHRNA7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia.PMID 12470124Read ↗

Association of the 5'-upstream regulatory region of the alpha7 nicotinic acetylcholine receptor subunit gene (CHRNA7) with schizophrenia.Semantic proximity Read ↗

The promoter -194 C polymorphism of the nicotinic alpha 7 receptor gene has a protective effect against the P50 sensory gating deficit.Semantic proximity Read ↗

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Identification of molecular variants at the promoter region of the human alpha 7 neuronal nicotinic acetylcholine receptor subunit gene but lack of association with schizophrenia.Semantic proximity Read ↗

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