Article
Comparison of polymorphisms in the alpha7 nicotinic receptor gene and its partial duplication in schizophrenic and control subjects.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 15 Nov 2003
Gault Judith, Hopkins Janet, Berger Ralph, Drebing Carla, Logel Judith, Walton Catherine, Short Margaret, Vianzon Ruby, Olincy Ann, Ross Randal G, Adler Lawrence E, Freedman Robert, Leonard Sherry
Abstract excerpt
The hypothesis that the 15q13-15 region of chromosome 15 contains a gene that contributes to the etiology of schizophrenia is supported by multiple genetic linkage studies. The alpha7 neuronal nicotinic acetylcholine receptor (CHRNA7) gene was selected as the best candidate gene in this region for molecular investigation, based on these linkage findings and biological evidence in both human and rodent models....
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