Article
The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases.
Cell - 5 May 2006
Song Kunhua, Backs Johannes, McAnally John, Qi Xiaoxia, Gerard Robert D, Richardson James A, Hill Joseph A, Bassel-Duby Rhonda, Olson Eric N
Abstract excerpt
Postnatal cardiac myocytes respond to diverse signals by hypertrophic growth and activation of a fetal gene program. In an effort to discover regulators of cardiac hypertrophy, we performed a eukaryotic expression screen for activators of the atrial natriuretic factor (ANF) gene, a cardiac-specific marker of hypertrophic signaling. We discovered that a family of transcriptional coactivators, called CAMTAs,...
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