Article
Excision of N-myc from chromosome 2 in human neuroblastoma cells containing amplified N-myc sequences.
Molecular and cellular biology - 1 Feb 1990
Hunt J D, Valentine M, Tereba A
Abstract excerpt
Amplification of one of three growth-stimulating myc genes is a common method by which many tumor types gain a proliferative advantage. In metastatic human neuroblastoma, the amplification of the N-myc locus, located on chromosome 2, is a dominant feature of this usually fatal pediatric cancer. Of the many models proposed to explain this amplification, all incorporate as the initial step either disproportionate...
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