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Article

Promoter SNPs in G1/S checkpoint regulators and their impact on the susceptibility to childhood leukemia.

Blood - 15 Jan 2007

Healy Jasmine, Bélanger Hélène, Beaulieu Patrick, Larivière Mathieu, Labuda Damian, Sinnett Daniel

Abstract excerpt

Mutations leading to the alteration of cell-cycle checkpoint functions are a common feature of most cancers. Because of the highly regulated nature of the cell cycle, it seems likely that variation in gene dosage of key components due to functional regulatory polymorphisms could play an important role in cancer development. Here we provide evidence of the involvement of promoter single-nucleotide polymorphisms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17008550
DOI: 10.1182/blood-2006-02-003236

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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