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Article

Functional promoter SNPs in cell cycle checkpoint genes.

Human molecular genetics - 15 Sept 2005

Bélanger Hélène, Beaulieu Patrick, Moreau Claudia, Labuda Damian, Hudson Thomas J, Sinnett Daniel

Abstract excerpt

A substantial number of genes mutated in human cancers encode components of the cell cycle processes. As the G1/S transition in the cell cycle is a finely regulated biological process, we hypothesized that sequence variations in the promoter region of the related genes might indeed lead to abnormal expression, thus predisposing the individuals carrying these genetic variants to cancer. In this report, we screened...

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Identifiers

PMID: 16081466
DOI: 10.1093/hmg/ddi298

Genes

CCND1
HDAC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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