Article
Temperature dependence of erythromelalgia mutation L858F in sodium channel Nav1.7.
Molecular pain - 19 Jan 2007
Han Chongyang, Lampert Angelika, Rush Anthony M, Dib-Hajj Sulayman D, Wang Xiaoliang, Yang Yong, Waxman Stephen G
Abstract excerpt
BACKGROUND: The disabling chronic pain syndrome erythromelalgia (also termed erythermalgia) is characterized by attacks of burning pain in the extremities induced by warmth. Pharmacological treatment is often ineffective, but the pain can be alleviated by cooling of the limbs. Inherited erythromelalgia has recently been linked to mutations in the gene SCN9A, which encodes the voltage-gated sodium channel Nav1.7....
Topics
- Analysis of Variance
- Cell Line, Transformed
- Dose-Response Relationship, Radiation
- Electric Stimulation
- Erythromelalgia
- Humans
- Leucine
- Membrane Potentials
- Mutation
- Patch-Clamp Techniques
- Phenylalanine
- Sodium Channels
- Temperature
- Transfection