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Article

Erythromelalgia mutation L823R shifts activation and inactivation of threshold sodium channel Nav1.7 to hyperpolarized potentials.

Biochemical and biophysical research communications - 11 Dec 2009

Lampert Angelika, Dib-Hajj Sulayman D, Eastman Emmanuella M, Tyrrell Lynda, Lin Zhimiao, Yang Yong, Waxman Stephen G

Abstract excerpt

Erythromelalgia (also termed erythermalgia) is a neuropathic pain syndrome, characterized by severe burning pain combined with redness in the extremities, triggered by mild warmth. The inherited form of erythromelalgia (IEM) has recently been linked to mutations in voltage-gated sodium channel Nav1.7, which is expressed in peripheral nociceptors. Here, we used whole-cell voltage-clamp recordings in HEK293 cells...

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Identifiers

PMID: 19800314
DOI: 10.1016/j.bbrc.2009.09.121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Erythromelalgia mutation L823R shifts activation and inactivation of threshold sodium channel Nav1.7 to hyperpolarized potentials.PMID 19800314Read ↗

Na(V)1.7 mutant A863P in erythromelalgia: effects of altered activation and steady-state inactivation on excitability of nociceptive dorsal root ganglion neurons.Semantic proximity Read ↗

Novel mutations mapping to the fourth sodium channel domain of Nav1.7 result in variable clinical manifestations of primary erythromelalgia.Semantic proximity Read ↗

Size matters: Erythromelalgia mutation S241T in Nav1.7 alters channel gating.Semantic proximity Read ↗

Temperature dependence of erythromelalgia mutation L858F in sodium channel Nav1.7.Semantic proximity Read ↗

NaV1.7 gain-of-function mutations as a continuum: A1632E displays physiological changes associated with erythromelalgia and paroxysmal extreme pain disorder mutations and produces symptoms of both disorders.Semantic proximity Read ↗

Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons.Semantic proximity Read ↗

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