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Article

Na(V)1.7 mutant A863P in erythromelalgia: effects of altered activation and steady-state inactivation on excitability of nociceptive dorsal root ganglion neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 29 Nov 2006

Harty T Patrick, Dib-Hajj Sulayman D, Tyrrell Lynda, Blackman Rachael, Hisama Fuki M, Rose John B, Waxman Stephen G

Abstract excerpt

Inherited erythromelalgia/erythermalgia (IEM) is a neuropathy characterized by pain and redness of the extremities that is triggered by warmth. IEM has been associated with missense mutations of the voltage-gated sodium channel Na(V)1.7, which is preferentially expressed in most nociceptive dorsal root ganglia (DRGs) and sympathetic ganglion neurons. Several mutations occur in cytoplasmic linkers of Na(V)1.7,...

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Identifiers

PMID: 17135418
DOI: 10.1523/JNEUROSCI.3424-06.2006
PMCID: PMC6674913

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Na(V)1.7 mutant A863P in erythromelalgia: effects of altered activation and steady-state inactivation on excitability of nociceptive dorsal root ganglion neurons.PMID 17135418Read ↗

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