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Article

Sodium channel Nav1.7 in vascular myocytes, endothelium, and innervating axons in human skin.

Molecular pain - 9 May 2015

Rice Frank L, Albrecht Phillip J, Wymer James P, Black Joel A, Merkies Ingemar Sj, Faber Catharina G, Waxman Stephen G

Abstract excerpt

BACKGROUND: The skin is a morphologically complex organ that serves multiple complementary functions, including an important role in thermoregulation, which is mediated by a rich vasculature that is innervated by sympathetic and sensory endings. Two autosomal dominant disorders characterized by episodes of severe pain, inherited erythromelalgia (IEM) and paroxysmal extreme pain disorder (PEPD) have been directly...

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Identifiers

PMID: 25957174
DOI: 10.1186/s12990-015-0024-3
PMCID: PMC4447014

Genes

PEPD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sodium channel Nav1.7 in vascular myocytes, endothelium, and innervating axons in human skin.PMID 25957174Read ↗

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Electrophysiological properties of mutant Nav1.7 sodium channels in a painful inherited neuropathy.Semantic proximity Read ↗

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