Electrophysiological properties of mutant Nav1.7 sodium channels in a painful inherited neuropathy.

Abstract excerpt

Although the physiological basis of erythermalgia, an autosomal dominant painful neuropathy characterized by redness of the skin and intermittent burning sensation of extremities, is not known, two mutations of Na(v)1.7, a sodium channel that produces a tetrodotoxin-sensitive, fast-inactivating current that is preferentially expressed in dorsal root ganglia (DRG) and sympathetic ganglia neurons, have recently...

Topics

• Amino Acid Substitution
• Cell Line
• Electrophysiology
• Erythromelalgia
• Genes, Dominant
• Humans
• Mutation
• NAV1.7 Voltage-Gated Sodium Channel
• Neuralgia
• Patch-Clamp Techniques
• Sodium Channels