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Article

Damage to the glycoshield activates PMT‐directed O‐mannosylation via the Msb2–Cek1 pathway in Candida albicans

7 Mar 2011

Abstract excerpt

Protein-O-mannosyltransferases (Pmt) transfer mannosyl residues to secretory proteins. Five isoforms of Pmt proteins in the human fungal pathogen Candida albicans have distinct functions in growth, morphogenesis and antifungal resistance. We found that PMT genes encoding the major isoforms Pmt1, Pmt2, Pmt4 are regulated differently in response to impaired glycostructures. While the PMT1 transcript level increased...

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Share to Antifungal resistance and susceptibility
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21375589
DOI: 10.1111/j.1365-2958.2011.07604.x

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