Article

A genetically encoded biosensor reveals heterogenous cAMP dynamics coordinating growth and resuscitation in Mycobacterium tuberculosis

2026-06-03

Abstract excerpt

3′,5′- Cyclic adenosine monophosphate (cAMP) serves as a global regulatory hub in Mycobacterium tuberculosis (Mtb), which dedicates approximately 1% of its genome to the synthesis, degradation and sensing of this secondary messenger. Despite cAMP’s central role in Mtb virulence and metabolic adaptation, we currently do not have any tools to monitor cAMP dynamics in real time at single-cell resolution. Here, we re...

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Literature Corpus work: c2c89aef-ca3e-5b94-8111-a9020f700e79
DOI: 10.64898/2026.06.02.729633

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