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Article

Clinically relevant mutations in the PhoR sensor kinase of host-adapted Mycobacterium abscessus isolates impact response to acidic pH and virulence.

Microbiology spectrum - 12 Dec 2023

Belardinelli Juan M, Arora Divya, Avanzi Charlotte, Wheat William H, Bryant Josephine M, Spencer John S, Blundell Tom L, Parkhill Julian, Floto R Andres, Jackson Mary

Abstract excerpt

IMPORTANCE: Difficult-to-treat pulmonary infections caused by nontuberculous mycobacteria of the Mycobacterium abscessus group have been steadily increasing in the USA and globally. Owing to the relatively recent recognition of M. abscessus as a human pathogen, basic and translational research to address critical gaps in diagnosis, treatment, and prevention of diseases caused by this microorganism has been...

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Identifiers

PMID: 37874174
DOI: 10.1128/spectrum.01588-23
PMCID: PMC10715180

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