Article

The role of transcriptional regulation in maintaining the availability of mycobacterial adenylate cyclases

2013-12-27

Abstract excerpt

Mycobacterium species have a complex cAMP regulatory network indicated by the high number of adenylate cyclases annotated in their genomes. However the need for a high level of redundancy in adenylate cyclase genes remains unknown. We have used semiquantitiative RT-PCR to examine the expression of the eight Mycobacterium smegmatis cyclases with orthologs in the human pathogen Mycobacterium tuberculosis , where c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9cd7f95d-b608-57c2-85a5-046df5d37bcd
DOI: 10.7287/peerj.preprints.177v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The role of transcriptional regulation in maintaining the availability of mycobacterial adenylate cyclasesDOI 10.7287/peerj.preprints.177v1Read

Identification of Cyclic AMP-Regulated Genes in Mycobacterium tuberculosis Complex Bacteria under Low-Oxygen ConditionsSemantic proximity Read

Cyclic AMP signalling in mycobacteria: redirecting the conversation with a common currencySemantic proximity Read

A Mycobacterial Cyclic AMP Phosphodiesterase That Moonlights as a Modifier of Cell Wall PermeabilitySemantic proximity Read

Paralogous cAMP receptor proteins in Mycobacterium smegmatis show biochemical and functional divergence.Semantic proximity Read

2′-5′-Oligoadenylate synthetase-like protein inhibits intracellular M. tuberculosis replication and promotes proinflammatory cytokine secretionSemantic proximity Read

Comparative transcriptomics reveals key gene expression differences between the human and bovine pathogens of the Mycobacterium tuberculosis complexSemantic proximity Read

Exploring the evolutionary divergence of cyclic di-nucleotide signaling in diverse mycobacterial speciesSemantic proximity Read

A genetically encoded biosensor reveals heterogenous cAMP dynamics coordinating growth and resuscitation in Mycobacterium tuberculosisSemantic proximity Read

Comparison of mammalian cell entry operons of mycobacteria: in silico analysis and expression profilingSemantic proximity Read

Convergence of two global regulators to coordinate expression of essential virulence determinants of <i>Mycobacterium tuberculosis</i>Semantic proximity Read

Analysis of Expression Profile of Mammalian Cell Entry ( mce ) Operons of Mycobacterium tuberculosisSemantic proximity Read

The promoter of Rv0560c is induced by salicylate and structurally-related compounds in Mycobacterium tuberculosis.Semantic proximity Read