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Article

Role of Toll-Like Receptor 13 in Innate Immune Recognition of Group B Streptococci

16 Sept 2014

Abstract excerpt

Murine Toll-like receptor 13 (TLR13), an endosomal receptor that is not present in humans, is activated by an unmethylated motif present in the large ribosomal subunit of bacterial RNA (23S rRNA). Little is known, however, of the impact of TLR13 on antibacterial host defenses. Here we examined the role of this receptor in the context of infection induced by the model pathogen group B streptococcus (GBS). To this...

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PMID: 25225249
DOI: 10.1128/iai.02282-14

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