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Article

The role of DNA sensing and innate immune receptor TLR9 in otitis media

14 Jan 2011

Abstract excerpt

Otitis media (OM), a common infectious disease in children, is associated with bacterial middle ear (ME) infection. Toll-like receptors (TLRs) are important mediators of innate immune responses, and TLR9 specifically recognizes the unmethylated cytidine-phosphate-guanosine (CpG) motifs in bacterial DNA. Additional sensors of foreign DNA have recently been identified. The role of DNA sensing and TLR9 was...

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PMID: 21239460
DOI: 10.1177/1753425910393539

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