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Article

Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis.

The Journal of clinical investigation - 1 Feb 2006

Prinz Marco, Garbe Folker, Schmidt Hauke, Mildner Alexander, Gutcher Ilona, Wolter Karina, Piesche Matthias, Schroers Roland, Weiss Elisabeth, Kirschning Carsten J, Rochford Christian D P, Brück Wolfgang, Becher Burkhard

Abstract excerpt

Inflammatory diseases of the CNS, such as MS and its animal model EAE, are characterized by infiltration of activated lymphocytes and phagocytes into the CNS. Within the CNS, activation of resident cells initiates an inflammatory cascade, leading to tissue destruction, demyelination, and neurologic deficit. TLRs recognize microbes and are pivotal mediators of innate immunity. Within the CNS, augmented TLR...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Encephalomyelitis, Autoimmune, Experimental

Share to Immunity, Innate

Share to Myeloid Differentiation Factor 88

Share to Toll-Like Receptor 2

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Source

Open in PubMed Open full text

Identifiers

PMID: 16440059
DOI: 10.1172/JCI26078
PMCID: PMC1350999

Genes

TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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