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Article

Homologues of oxysterol-binding proteins affect Cdc42p- and Rho1p-mediated cell polarization in Saccharomyces cerevisiae.

Traffic (Copenhagen, Denmark) - 1 Sept 2006

Kozminski Keith G, Alfaro Gabriel, Dighe Shubha, Beh Christopher T

Abstract excerpt

Polarized cell growth requires the establishment of an axis of growth along which secretion can be targeted to a specific site on the cell cortex. How polarity establishment and secretion are choreographed is not fully understood, though Rho GTPase- and Rab GTPase-mediated signaling is required. Superimposed on this regulation are the functions of specific lipids and their cognate binding proteins. In a screen...

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Source

Identifiers

PMID: 17004323
DOI: 10.1111/j.1600-0854.2006.00467.x

Genes

CDC42
OSBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Homologues of oxysterol-binding proteins affect Cdc42p- and Rho1p-mediated cell polarization in Saccharomyces cerevisiae.PMID 17004323Read ↗

The sterol-binding protein Kes1/Osh4p is a regulator of polarized exocytosis.Semantic proximity Read ↗

Nonvesicular sterol movement from plasma membrane to ER requires oxysterol-binding protein-related proteins and phosphoinositides.Semantic proximity Read ↗

Overlapping functions of the yeast oxysterol-binding protein homologues.Semantic proximity Read ↗

Dual targeting of Osh1p, a yeast homologue of oxysterol-binding protein, to both the Golgi and the nucleus-vacuole junction.Semantic proximity Read ↗

A role for yeast oxysterol-binding protein homologs in endocytosis and in the maintenance of intracellular sterol-lipid distribution.Semantic proximity Read ↗

Osh4p is needed to reduce the level of phosphatidylinositol-4-phosphate on secretory vesicles as they mature.Semantic proximity Read ↗

Kes1p shares homology with human oxysterol binding protein and participates in a novel regulatory pathway for yeast Golgi-derived transport vesicle biogenesis.Semantic proximity Read ↗

AAA ATPases regulate membrane association of yeast oxysterol binding proteins and sterol metabolism.Semantic proximity Read ↗

The Rho GTPase Rho3 has a direct role in exocytosis that is distinct from its role in actin polarity.Semantic proximity Read ↗

Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues.Semantic proximity Read ↗

A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein.Semantic proximity Read ↗

Cdc42 interacts with the exocyst and regulates polarized secretion.Semantic proximity Read ↗

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