Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein.

Yeast (Chichester, England) - 1 Mar 1994

Jiang B, Brown J L, Sheraton J, Fortin N, Bussey H

Abstract excerpt

We have identified three yeast genes, KES1, HES1 and OSH1, whose products show homology to the human oxysterol binding protein (OSBP). Mutations in these genes resulted in pleiotropic sterol-related phenotypes. These include tryptophan-transport defects and nystatin resistance, shown by double and triple mutants. In addition, mutant combinations showed small but apparently cumulative reductions in membrane...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Chromosome Mapping
Share to Fungal Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Fungal

Share to Molecular Sequence Data

Share to Mutation

Share to Phenotype

Share to Saccharomyces cerevisiae

Source

Identifiers

PMID: 8017104
DOI: 10.1002/yea.320100307

Genes

HES1
OSBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein.PMID 8017104Read ↗

Overlapping functions of the yeast oxysterol-binding protein homologues.Semantic proximity Read ↗

Kes1p shares homology with human oxysterol binding protein and participates in a novel regulatory pathway for yeast Golgi-derived transport vesicle biogenesis.Semantic proximity Read ↗

A role for yeast oxysterol-binding protein homologs in endocytosis and in the maintenance of intracellular sterol-lipid distribution.Semantic proximity Read ↗

The OSBP-related protein family in humansSemantic proximity Read ↗

Nonvesicular sterol movement from plasma membrane to ER requires oxysterol-binding protein-related proteins and phosphoinositides.Semantic proximity Read ↗

Homologues of oxysterol-binding proteins affect Cdc42p- and Rho1p-mediated cell polarization in Saccharomyces cerevisiae.Semantic proximity Read ↗

The sterol-binding protein Kes1/Osh4p is a regulator of polarized exocytosis.Semantic proximity Read ↗

Yeast as a Model to Understand Actin-Mediated Cellular Functions in Mammals—Illustrated with Four Actin Cytoskeleton ProteinsSemantic proximity Read ↗

AAA ATPases regulate membrane association of yeast oxysterol binding proteins and sterol metabolism.Semantic proximity Read ↗

Dual targeting of Osh1p, a yeast homologue of oxysterol-binding protein, to both the Golgi and the nucleus-vacuole junction.Semantic proximity Read ↗

A Family of 12 Human Genes Containing Oxysterol-Binding DomainsSemantic proximity Read ↗

Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.