A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein.

doi:10.1002/yea.320100307

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Article

A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein.

Yeast (Chichester, England) - 1 Mar 1994

Jiang B, Brown J L, Sheraton J, Fortin N, Bussey H

Abstract excerpt

We have identified three yeast genes, KES1, HES1 and OSH1, whose products show homology to the human oxysterol binding protein (OSBP). Mutations in these genes resulted in pleiotropic sterol-related phenotypes. These include tryptophan-transport defects and nystatin resistance, shown by double and triple mutants. In addition, mutant combinations showed small but apparently cumulative reductions in membrane...

Topics

Amino Acid Sequence
Biological Transport
Carrier Proteins
Chromosome Mapping
Drug Resistance, Microbial
Ergosterol
Fungal Proteins
Genes, Fungal
Humans
Membrane Proteins
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multigene Family

Mutation

Nystatin

Phenotype

Receptors, Steroid

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Source

Open in PubMed

Identifiers

PMID: 8017104
DOI: 10.1002/yea.320100307

Genes

HES1
OSBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8017104-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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