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Article

Cdc42 interacts with the exocyst and regulates polarized secretion.

The Journal of biological chemistry - 14 Dec 2001

Zhang X, Bi E, Novick P, Du L, Kozminski K G, Lipschutz J H, Guo W

Abstract excerpt

Polarized delivery and incorporation of proteins and lipids to specific domains of the plasma membrane is fundamental to a wide range of biological processes such as neuronal synaptogenesis and epithelial cell polarization. The exocyst complex is specifically localized to sites of active exocytosis and plays essential roles in secretory vesicle targeting and docking at the plasma membrane. Sec3p, a component of...

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PMID: 11595741
DOI: 10.1074/jbc.M107464200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Click a neighbor to travelStep 1 · 12 closest

Cdc42 interacts with the exocyst and regulates polarized secretion.PMID 11595741Read ↗

Yeast Cdc42 functions at a late step in exocytosis, specifically during polarized growth of the emerging bud.Semantic proximity Read ↗

Rho GTPase regulation of exocytosis in yeast is independent of GTP hydrolysis and polarization of the exocyst complex.Semantic proximity Read ↗

Cyclical regulation of the exocyst and cell polarity determinants for polarized cell growth.Semantic proximity Read ↗

Exo-endocytic trafficking and the septin-based diffusion barrier are required for the maintenance of Cdc42p polarization during budding yeast asymmetric growth.Semantic proximity Read ↗

The Rho GTPase Rho3 has a direct role in exocytosis that is distinct from its role in actin polarity.Semantic proximity Read ↗

Sec2p mediates nucleotide exchange on Sec4p and is involved in polarized delivery of post-Golgi vesicles.Semantic proximity Read ↗

Transbilayer phospholipid flipping regulates Cdc42p signaling during polarized cell growth via Rga GTPase-activating proteins.Semantic proximity Read ↗

Sec3p is a spatial landmark for polarized secretion in budding yeast.Semantic proximity Read ↗

The synaptobrevin homologue Snc2p recruits the exocyst to secretory vesicles by binding to Sec6pSemantic proximity Read ↗

Distinct Cdc42 protein levels differentially regulate polarized growth and cell fusion in Schizosaccharomyces pombe.Semantic proximity Read ↗

Cdc42 regulates multiple membrane traffic events in fission yeast.Semantic proximity Read ↗

Regulation of cell polarity by interactions of Msb3 and Msb4 with Cdc42 and polarisome components.Semantic proximity Read ↗

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