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Article

The Rho GTPase Rho3 has a direct role in exocytosis that is distinct from its role in actin polarity.

Molecular biology of the cell - 1 Dec 1999

Adamo J E, Rossi G, Brennwald P

Abstract excerpt

Budding yeast grow asymmetrically by the polarized delivery of proteins and lipids to specific sites on the plasma membrane. This requires the coordinated polarization of the actin cytoskeleton and the secretory apparatus. We identified Rho3 on the basis of its genetic interactions with several late-acting secretory genes. Mutational analysis of the Rho3 effector domain reveals three distinct functions in cell...

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Identifiers

PMID: 10588647
DOI: 10.1091/mbc.10.12.4121
PMCID: PMC25747

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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The Rho GTPase Rho3 has a direct role in exocytosis that is distinct from its role in actin polarity.PMID 10588647Read ↗

Rho3 of Saccharomyces cerevisiae, which regulates the actin cytoskeleton and exocytosis, is a GTPase which interacts with Myo2 and Exo70.Semantic proximity Read ↗

Rho GTPase regulation of exocytosis in yeast is independent of GTP hydrolysis and polarization of the exocyst complex.Semantic proximity Read ↗

Yeast Cdc42 functions at a late step in exocytosis, specifically during polarized growth of the emerging bud.Semantic proximity Read ↗

The GTPase-activating protein Rga1 interacts with Rho3 GTPase and may regulate its function in polarized growth in budding yeast.Semantic proximity Read ↗

Cdc42 interacts with the exocyst and regulates polarized secretion.Semantic proximity Read ↗

Sec3p is a spatial landmark for polarized secretion in budding yeast.Semantic proximity Read ↗

The secretory pathway mediates localization of the cell polarity regulator Aip3p/Bud6p.Semantic proximity Read ↗

Lethal giant larvae proteins interact with the exocyst complex and are involved in polarized exocytosis.Semantic proximity Read ↗

Regulation of cell polarity by interactions of Msb3 and Msb4 with Cdc42 and polarisome components.Semantic proximity Read ↗

Exo70p mediates the secretion of specific exocytic vesicles at early stages of the cell cycle for polarized cell growth.Semantic proximity Read ↗

An internal domain of Exo70p is required for actin-independent localization and mediates assembly of specific exocyst components.Semantic proximity Read ↗

Identification of genes controlling growth polarity in the budding yeast Saccharomyces cerevisiae: a possible role of N-glycosylation and involvement of the exocyst complex.Semantic proximity Read ↗

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