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Article

Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues.

The Journal of cell biology - 14 Dec 2009

Schulz Timothy A, Choi Mal-Gi, Raychaudhuri Sumana, Mears Jason A, Ghirlando Rodolfo, Hinshaw Jenny E, Prinz William A

Abstract excerpt

Sterols are transferred between cellular membranes by vesicular and poorly understood nonvesicular pathways. Oxysterol-binding protein-related proteins (ORPs) have been implicated in sterol sensing and nonvesicular transport. In this study, we show that yeast ORPs use a novel mechanism that allows regulated sterol transfer between closely apposed membranes, such as organelle contact sites. We find that the core...

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Identifiers

PMID: 20008566
DOI: 10.1083/jcb.200905007
PMCID: PMC2806323

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Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues.PMID 20008566Read ↗

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