Article
Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues.
The Journal of cell biology - 14 Dec 2009
Schulz Timothy A, Choi Mal-Gi, Raychaudhuri Sumana, Mears Jason A, Ghirlando Rodolfo, Hinshaw Jenny E, Prinz William A
Abstract excerpt
Sterols are transferred between cellular membranes by vesicular and poorly understood nonvesicular pathways. Oxysterol-binding protein-related proteins (ORPs) have been implicated in sterol sensing and nonvesicular transport. In this study, we show that yeast ORPs use a novel mechanism that allows regulated sterol transfer between closely apposed membranes, such as organelle contact sites. We find that the core...
Topics
- Binding Sites
- Biological Transport
- Carrier Proteins
- Endoplasmic Reticulum
- Kinetics
- Liposomes
- Membrane Lipids
- Membrane Proteins
- Models, Molecular
- Mutation
- Phosphatidylinositols
- Protein Conformation
- Protein Structure, Tertiary