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Article

AAA ATPases regulate membrane association of yeast oxysterol binding proteins and sterol metabolism.

The EMBO journal - 7 Sept 2005

Wang Penghua, Zhang Yong, Li Hongzhe, Chieu Hai Kee, Munn Alan L, Yang Hongyuan

Abstract excerpt

The yeast genome encodes seven oxysterol binding protein homologs, Osh1p-Osh7p, which have been implicated in regulating intracellular lipid and vesicular transport. Here, we show that both Osh6p and Osh7p interact with Vps4p, a member of the AAA (ATPases associated with a variety of cellular activities) family. The coiled-coil domain of Osh7p was found to interact with Vps4p in a yeast two-hybrid screen and the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16096648
DOI: 10.1038/sj.emboj.7600764
PMCID: PMC1201346

Genes

OSBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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AAA ATPases regulate membrane association of yeast oxysterol binding proteins and sterol metabolism.PMID 16096648Read ↗

The sterol-binding protein Kes1/Osh4p is a regulator of polarized exocytosis.Semantic proximity Read ↗

A role for yeast oxysterol-binding protein homologs in endocytosis and in the maintenance of intracellular sterol-lipid distribution.Semantic proximity Read ↗

Osh4p is needed to reduce the level of phosphatidylinositol-4-phosphate on secretory vesicles as they mature.Semantic proximity Read ↗

Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues.Semantic proximity Read ↗

Nonvesicular sterol movement from plasma membrane to ER requires oxysterol-binding protein-related proteins and phosphoinositides.Semantic proximity Read ↗

Homologues of oxysterol-binding proteins affect Cdc42p- and Rho1p-mediated cell polarization in Saccharomyces cerevisiae.Semantic proximity Read ↗

Dual targeting of Osh1p, a yeast homologue of oxysterol-binding protein, to both the Golgi and the nucleus-vacuole junction.Semantic proximity Read ↗

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Vesicle-associated membrane protein-associated protein-A (VAP-A) interacts with the oxysterol-binding protein to modify export from the endoplasmic reticulum.Semantic proximity Read ↗

Identification and assessment of the role of a nominal phospholipid binding region of ORP1S (oxysterol-binding-protein-related protein 1 short) in the regulation of vesicular transport.Semantic proximity Read ↗

Kes1p shares homology with human oxysterol binding protein and participates in a novel regulatory pathway for yeast Golgi-derived transport vesicle biogenesis.Semantic proximity Read ↗

A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein.Semantic proximity Read ↗

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