Article
Overlapping functions of the yeast oxysterol-binding protein homologues.
Genetics - 1 Mar 2001
Beh C T, Cool L, Phillips J, Rine J
Abstract excerpt
The Saccharomyces cerevisiae genome encodes seven homologues of the mammalian oxysterol-binding protein (OSBP), a protein implicated in lipid trafficking and sterol homeostasis. To determine the functions of the yeast OSBP gene family (OSH1-OSH7), we used a combination of genetics, genomics, and sterol lipid analysis to characterize OSH deletion mutants. All 127 combinations and permutations of OSH deletion...
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