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Article

Kinin-dependent hypersensitivity reactions in hemodialysis: metabolic and genetic factors.

Kidney international - 1 Nov 2006

Molinaro G, Duan Q L, Chagnon M, Moreau M E, Simon P, Clavel P, Lavaud S, Boileau G, Rouleau G A, Lepage Y, Adam A, Chanard J

Abstract excerpt

Although the association of angiotensin I-converting enzyme inhibitors (ACEis) with a negatively charged membrane is thought to be responsible for hypersensitivity reactions (HSRs) during hemodialysis, we hypothesize that these complications are due to changes in plasma aminopeptidase P (APP) activity and genotype. To test this hypothesis, we measured plasma APP activity in 14 patients who suffered HSR (HSR+)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17003818
DOI: 10.1038/sj.ki.5001873

Genes

APP
XPNPEP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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