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Article

Sex-dependent and race-dependent association of XPNPEP2 C-2399A polymorphism with angiotensin-converting enzyme inhibitor-associated angioedema.

Pharmacogenetics and genomics - 1 Sept 2010

Woodard-Grice Alencia V, Lucisano Amelia C, Byrd James B, Stone Elizabeth R, Simmons William H, Brown Nancy J

Abstract excerpt

BACKGROUND: Angioedema is a rare adverse effect of angiotensin-converting enzyme (ACE) inhibitors, which occurs more commonly in women and black Americans. Angioedema is thought to result from decreased degradation of vasoactive peptides. During ACE inhibition, bradykinin is primarily inactivated by aminopeptidase P (APP). Earlier studies have provided conflicting data with regard to serum APP activity in...

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Source

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Identifiers

PMID: 20625347
DOI: 10.1097/FPC.0b013e32833d3acb
PMCID: PMC2945219

Genes

APP
ACE
XPNPEP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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