A variant in XPNPEP2 is associated with angioedema induced by angiotensin I-converting enzyme inhibitors.

doi:10.1086/496899

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Article

A variant in XPNPEP2 is associated with angioedema induced by angiotensin I-converting enzyme inhibitors.

American journal of human genetics - 1 Oct 2005

Duan Qing Ling, Nikpoor Borzoo, Dube Marie-Pierre, Molinaro Giuseppe, Meijer Inge A, Dion Patrick, Rochefort Daniel, Saint-Onge Judith, Flury Leah, Brown Nancy J, Gainer James V, Rouleau Jean L, Agostoni Angelo, Cugno Massimo, Simon Pierre, Clavel Pierre, Potier Jacky, Wehbe Bassem, Benarbia Seddik, Marc-Aurele Julien, Chanard Jacques, Foroud Tatiana, Adam Albert, Rouleau Guy A

Abstract excerpt

Angiotensin I-converting enzyme inhibitors (ACEi), which are used to treat common cardiovascular diseases, are associated with a potentially life-threatening adverse reaction known as angioedema (AE-ACEi). We have previously documented a significant association between AE-ACEi and low plasma aminopeptidase P (APP) activity. With eight large pedigrees, we hereby demonstrate that this quantitative trait is...

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Identifiers

PMID: 16175507
DOI: 10.1086/496899
PMCID: PMC1275610

Genes

APP
XPNPEP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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