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Article

Insulin resistance and increased pancreatic beta-cell proliferation in mice expressing a mutant insulin receptor (P1195L).

The Journal of endocrinology - 1 Sept 2006

Ogino J, Sakurai K, Yoshiwara K, Suzuki Yoichi, Ishizuka N, Seki N, Suzuki Yoshifumi, Koseki H, Shirasawa T, Hashimoto N, Yagui K, Saito Y

Abstract excerpt

Several mutations of the tyrosine kinase domain of insulin receptor (IR) have been clinically reported to lead insulin resistance and insulin hypersecretion in humans. However, it has not been completely clarified how insulin resistance and pancreatic beta-cell function affect each other under the expression of mutant IR. We investigated the response of pancreatic beta-cells in mice carrying a mutation (P1195L)...

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Source

Identifiers

PMID: 17003275
DOI: 10.1677/joe.1.06849

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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