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Article

Hyperinsulinemia but no diabetes in transgenic mice homozygously expressing the tyrosine kinase-deficient human insulin receptor.

Biochemical and biophysical research communications - 17 Nov 1997

Wang L, Muromoto N, Hayashi H, Mitani Y, Uehara H, Izumi K, Ebina Y

Abstract excerpt

We generated transgenic mice homozygous for the tyrosine kinase-deficient human insulin receptor (hIRK1030M(+/+)) under control of the insulin receptor promoter. Similar growth patterns and results of glucose tolerance tests were observed among normal, heterozygous, and homozygous mice. Insulin tolerance test indicated no significant difference in the hypoglycemic response to insulin among the three genotypes....

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Identifiers

PMID: 9388499
DOI: 10.1006/bbrc.1997.7677

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