Article
Hyperinsulinemia but no diabetes in transgenic mice homozygously expressing the tyrosine kinase-deficient human insulin receptor.
Biochemical and biophysical research communications - 17 Nov 1997
Wang L, Muromoto N, Hayashi H, Mitani Y, Uehara H, Izumi K, Ebina Y
Abstract excerpt
We generated transgenic mice homozygous for the tyrosine kinase-deficient human insulin receptor (hIRK1030M(+/+)) under control of the insulin receptor promoter. Similar growth patterns and results of glucose tolerance tests were observed among normal, heterozygous, and homozygous mice. Insulin t...
Topics
- Animals
- Blood Glucose
- Genotype
- Glucose Tolerance Test
- Homozygote
- Humans
- Hyperinsulinism
- Insulin
- Islets of Langerhans
- Mice
- Mice, Transgenic
- Point Mutation
- Receptor, Insulin