Both T-786C and G894T polymorphism of endothelial nitric oxide synthase affect in-vitro endothelium-dependent relaxation of internal mammary artery rings from patients with coronary artery disease.

doi:10.1097/01.hjr.0000230100.70900.37

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Article

Both T-786C and G894T polymorphism of endothelial nitric oxide synthase affect in-vitro endothelium-dependent relaxation of internal mammary artery rings from patients with coronary artery disease.

European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology - 1 Oct 2006

Erbs Sandra, Möbius-Winkler Sven, Linke Axel, Adams Volker, Doll Nicolas, Gielen Stephan, Gummert Jan F, Mohr Friedrich W, Schuler Gerhard, Hambrecht Rainer

Abstract excerpt

OBJECTIVES: Polymorphisms of endothelial nitric oxide synthase (eNOS) gene in the promoter (T-786C) and exon 7 (G894T) have been suggested to attenuate endothelial function. As it is unknown whether these polymorphisms, on top of classical risk factors, further deteriorate endothelium-dependent vasomotion, we aimed to elucidate the impact of both polymorphisms on the ex-vivo vasomotor function of left internal...

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PMID: 17001225
DOI: 10.1097/01.hjr.0000230100.70900.37

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