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Article

Relevance of the NOS3 T-786C and G894T variants for cholinergic and adrenergic coronary vasomotor responses in man.

Basic research in cardiology - 1 Sept 2005

Naber Ch K, Frey U H, Oldenburg O, Brauck K, Eggebrecht H, Schmermund A, Baumgart D, Erbel R, Siffert W, Heusch G

Abstract excerpt

OBJECTIVE: We investigated the impact of the -786C allele at the promoter and the 894T allele in exon 7 of the gene encoding the endothelial nitric oxide synthase (NOS3) on coronary vasomotor responses to exogenous and endogenous stimuli. METHODS: In 47 individuals undergoing coronary angiography for chest pain, but without significant stenosis in the left anterior descending artery (LAD), nitroglycerine and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16032374
DOI: 10.1007/s00395-005-0530-y

Genes

NOS3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Relevance of the NOS3 T-786C and G894T variants for cholinergic and adrenergic coronary vasomotor responses in man.PMID 16032374Read ↗

The T-786C endothelial nitric oxide synthase genotype is a novel risk factor for coronary artery disease in Caucasian patients of the GENICA study.Semantic proximity Read ↗

A T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene and coronary arterial vasomotility.Semantic proximity Read ↗

Both T-786C and G894T polymorphism of endothelial nitric oxide synthase affect in-vitro endothelium-dependent relaxation of internal mammary artery rings from patients with coronary artery disease.Semantic proximity Read ↗

Role of the eNOS Glu298Asp variant on the GNB3825T allele dependent determination of alpha-adrenergic coronary constriction.Semantic proximity Read ↗

The T-786C and Glu298Asp polymorphisms of the endothelial nitric oxide gene affect the forearm blood flow responses of Caucasian hypertensive patients.Semantic proximity Read ↗

Association of the T-786C polymorphism of the nitric oxide synthase 3 gene with acute coronary syndrome or premature coronary artery disease: A systematic review and meta-analysis.Semantic proximity Read ↗

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The 894G>T endothelial nitric oxide synthase genetic polymorphism affects hemodynamic responses to mental stress performed before and after exercise.Semantic proximity Read ↗

eNOS 894T allele and coronary blood flow at rest and during adenosine-induced hyperemia.Semantic proximity Read ↗

The T(-786)C endothelial nitric oxide synthase genotype predicts cardiovascular mortality in high-risk patients.Semantic proximity Read ↗

The T-786-->C mutation in endothelial nitric oxide synthase is associated with hypertension.Semantic proximity Read ↗

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