Article
The T-786C endothelial nitric oxide synthase genotype is a novel risk factor for coronary artery disease in Caucasian patients of the GENICA study.
Journal of the American College of Cardiology - 19 Mar 2003
Rossi Gian Paolo, Cesari Maurizio, Zanchetta Mario, Colonna Stefania, Maiolino Giuseppe, Pedon Luigi, Cavallin Martina, Maiolino Pietro, Pessina Achille C
Abstract excerpt
OBJECTIVES: We investigated the association of polymorphisms in the promoter region and exon 7 endothelial nitric oxide synthase (eNOS) gene with coronary artery disease (CAD). BACKGROUND: Endothelial dysfunction foretells cardiovascular events and can be genetically determined. METHODS: We genotyped for the promoter (T(-786)C) and exon 7 (Glu298Asp, G(894)T) polymorphisms in 1,225 subjects; 1,106 were...
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