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Article

An arc of unpaired "hinge bases" facilitates information exchange among functional centers of the ribosome.

Molecular and cellular biology - 1 Dec 2006

Rakauskaite Rasa, Dinman Jonathan D

Abstract excerpt

Information must be shared and functions coordinated among the spatially distinct functional centers of the ribosome. To address these issues, a yeast-based genetic system enabling generation of stable strains expressing only mutant forms of rRNA was devised. The B1a bridge (helix 38) has been implicated in the subtle modulation of numerous ribosomal functions. Base-specific mutations were introduced into helix...

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Identifiers

PMID: 17000775
DOI: 10.1128/MCB.01311-06
PMCID: PMC1636827

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Source receipt: pubmed, retrieved 7 Sept 2026.

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